Kite Advances Scalable Bioinformatics for Cell Therapy Research in Collaboration with AWS HealthOmics

This article describes how Kite Pharma, a Gilead company, modernized its bioinformatics infrastructure by migrating to AWS HealthOmics and building an event-driven architecture that integrates with their Electronic Laboratory Notebook system.

• Replaced fragmented, project-specific workflows with standardized cloud-enabled bioinformatics pipelines using AWS HealthOmics
• Implemented event-driven architecture connecting on-premises sequencers to AWS via DataSync, Lambda, EventBridge, and SQS
• Scientists trigger analyses through familiar ELN interface without CLI access or infrastructure knowledge required
• Deployed 20 bioinformatics workflows processing scRNA-seq, bulk RNA-seq, whole-exome sequencing, and protein structure prediction
• Expanded access to 100+ researchers through self-service ELN integration, reducing manual steps and operational overhead
• Achieved 18+ months of continuous production with five workflows fully integrated for self-service execution

Kite's cloud-native approach demonstrates how pharma organizations can modernize bioinformatics infrastructure while maintaining integration with existing laboratory systems, enabling scientists to focus on research rather than infrastructure management.